Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.
Lopez Ruíz, Heraclio
2011
Rodríguez-Garnica Cristina, López-Ruiz Heraclio,* Rojas-Lima Susana, Álvarez - Hernández Alejandro, Tapia-Benavides Rafael, García-López María Concepción. Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group. Journal of the Mexican Chemical Society, 55(3), 148-153. (2011)
Abstract
Novel chiral glycinate derivatives (S)-6 and (S)-7 containing the a-phenylethyl group, were prepared and studied as potentialprecursors of enantiopure a-substituted-a-amino acids. In particular, the alkylation of enolate (S)-7-Li showed substantial (78:22 dr)stereoinduction by the N-(1-phenylethyl)benzamide chiral auxiliary.Addition of DMPU showed no appreciable effect upon the diastereoselectivity
Artículos relacionados
Stereoselective addition of allylmagnesium chloride to the CN bond of [4.3.0] boron heterobicycles
Bis(acetylsalicylato-j2O,O00)diaquacadmium(II)
X-ray crystallographic study of neutral boron chelates with ?-diketones and tropolone
Study of the reactivity of squarylferrocenes. Addition of amines and aminoesters
Synthesis of new homochiral 2,3-dialkylpiperazines derived from (R)-(?)-phenylglycinol